IVF Trigger - Post Doctoral Fellowship in Reproductive Medicine
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- 17 Feb 2026
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Medline Academics provides a structured Post doctoral fellowship in reproductive medicine, especially designed for practicing gynaecologists who wish to gain advanced expertise in the management of infertility cases and assisted reproduction techniques.
Medline Academics provides a structured Post doctoral fellowship in reproductive medicine, especially designed for practicing gynaecologists who wish to gain advanced expertise in the management of infertility cases and assisted reproduction techniques. The program provides advanced training in the techniques of ovulation induction, trigger methods, intrauterine insemination, in vitro fertilization, embryo transfer, and the management of complications. Medline Academics provides advanced ivf fellowship clinical skills to the practitioners, which can be directly applied to the clinical practice of fertility care.
In this article today, we will talk about HCG Trigger Injection. In common language, it is known as Ovulation Injection or Trigger Shot Injection. HCG, which is full form of Human Chorionic Gonadotropin, is a pregnancy hormone which is released from placenta during pregnancy. Its main function is to support early pregnancy. We use HCG in clinical practise in two ways.
- First, for pregnancy hormone support.
- Second, for ovulation in infertility patients. Ovulation is used to release egg from follicle.
In today's video, we will talk about how HCG injection is used in infertility. What is its action? How is ovulation done? And in which infertility patients it is used? HCG hormone is used in infertility patients because its structure is similar to our natural ovulation hormone LH hormone. LH hormone and HCG hormone have similar chemical structure and action.
What is the function of LH hormone?
As soon as egg in our body reaches maturity level, i.e., its size is between 18-20 mm, LH hormone level starts rising in our body. This is known as LH surge. When LH hormone level is so high in our body, there are chemical reactions in egg follicle. As a result, egg finally reaches its maturity level. And ovulation of that egg is done. LH hormone level starts rising in our body and duration of ovulation is 36-48 hours.
When LH hormone peak in our body, after 36-48 hours, naturally our egg is released. And after that, LH hormone level comes down. Similarly, when we give HCG injection, its final maturation and ovulation is done. And when we give HCG injection, its final maturation and ovulation is done. In this way, we use HCG injection for ovulation. HCG injection comes in two forms.
- First is Urinary HCG and
- Second is Recombinant HCG. Recombinant HCG is a synthetic form.
In Urinary HCG, we give 5,000 to 10,000 doses which is intra-muscular. In Recombinant HCG, we give 250 microgramme dose which is subcutaneously. These doses are for infertility patients. In HCG injection, it is important to maintain cold chain.
Timing is also very important. Because we know that when we give HCG injection, after 36-48 hours, ovulation will happen. So, we give HCG injection according to the patients we are using.
Next, we will discuss how HCG injection is used in infertility. In clinical practise, we use HCG injection in three types of patients.
- First is for natural dry patients.
- Second is for IUI patients.
- Third is for IVF patients.
In all these patients, we start giving egg making medicines and through follicle study, we measure the size of follicles.
When these follicles are 18-20 mm in size, means when they mature, at that time, we use HCG injection. As we know that when we give HCG injection, after 36-48 hours, ovulation happens.
- So, the first set of patients who want to give natural dry, we normally advise them to give natural dry after 24-48 hours. Means you have to start natural dry from the next day. This will increase your pregnancy rate.
- The second set of patients is IUI patients. In IUI patients, we plan the IUI after 40 hours of HCG trigger shot. And before IUI, we document the ovulation with ultrasound.
- The third set of patients is for IVF patients. As we know that in IVF, we have to remove the eggs from the body. So, whenever we give trigger shot injection, we remove the eggs from the body for 34-35 hours. After 36 hours, if ovulation happens, these eggs will be released in the body and will be of no use to us. So, in IVF patients, the timing of trigger shot injection is very important. And whenever it is called at the exact time, you have to give this injection at the exact time.
Dr. Kamini Rao Hospitals is one of the best IVF hospital in Bangalore for high-tech fertility treatment and reproductive medicine study. They emphasize evidence-based practice and have years of experience in fertility treatment. They provide training and guidance in how to induce ovulation, trigger methods, IUI and IVF cycle methods, methods for embryo transfer, and how to deal with complications. They provide training in fertility treatment by combining academic knowledge with actual patient treatment with high-tech embryology equipment and qualified fertility experts.
What is the role of HCG injection in fertility treatment?
HCG injection is when we give medicines to the patient to make the seed and call the patient for sonography to check whether the seed is ready or not. When the seed is ready, the size of the seed should be at least 18 to 22 mm. Then we call that seed ready.
Sometimes the seed is small, 15 mm or 16 mm, then it is not a ripe seed, it is a raw seed. So, we never apply HCG injection on that seed. When the size of the seed is 18 to 22 mm, then we apply HCG injection.
What is the role of HCG injection? The role of HCG injection is ovulation. What is ovulation?
Ovulation is when the seed leaves the ovary and enters the fallopian tube. It is a very important step because if this does not happen, then our medicines become useless and the seed remains trapped in the ovary. And then there is no conception. So, HCG is a way by which the chances of pregnancy can be increased.
What should be the dose of HCG injection?
The dose of HCG injection can be anything between 5000 to 10,000. And then we assume that the patient will have ovulation after the injection. And we advise them to stay together for the next 4 to 5 days. So, is HCG injection harmful? No, HCG injection is absolutely safe.
When we apply HCG injection to the patient every month, then the patient feels that I don't know why I am applying it. What is the benefit of it? Is it harmful to apply something? So, let me clarify that HCG injection is a natural hormone. It secretes from the body during the time of ovulation.
And when the patient is pregnant, then also this hormone is important to continue the pregnancy of the patient. So, HCG injection not only helps the patient to conceive. Along with that, it also helps to carry the pregnancy.
Is it harmful? It is not harmful. But many times, if we have made multiple eggs of the patient by applying the injection, then due to HCG injection, there is a small chance that the patient will have ovulation and fill water in the stomach. But because we do all these things and apply the injection after the patient's sonography, then there is almost zero chance of such a possibility. So, you can apply HCG injection in your fertility treatment every month without any worries.
